BBSafe® is the most reliable non-invasive prenatal
genetic screening test on the market.
It detects the probability of chromosomal abnormalities that your baby could have
without any risk to you or your baby.
BBSafe®
What it is?
It is the most reliable non-invasive prenatal test on the market that analyzes circulating free fetal DNA. No risk for the mother or the baby.
Through a simple maternal blood sample, BBSafe® detects the most frequent chromosomal abnormalities in pregnancy such as Patau Syndrome (trisomy 13), Edwards Syndrome (trisomy 18) and Down Syndrome (trisomy 21), among others.
Through an exhaustive analysis of this DNA we look for signs of specific chromosomal alterations. With this information we elaborate a personalized report indicating the risks that the future baby has of suffering the different anomalies.
In addition, with this test you will also be able to know the sex of the baby with great precision whenever you wish.
BBSafe®
For whom it is suitable?
- Pregnancy from the 10th week of gestation onwards.
- In twin pregnancies 12th week of gestation.
- Can be performed in cases of assisted reproduction, including IVF with gamete donation.
3 options of BBSafe®
What do we analyze?
STANDARD
- Patau’s syndrome (trisomy chromosome 13)
- Edwards’ syndrome (trisomy chromosome 18)
- Down’s syndrome (trisomy chromosome 21)
- Turner, Klinefelter, XYY and triple X syndrome (sex chromosome aneuploidies)
- Foetal sex (optional)
PLUS
- Patau’s syndrome (trisomy chromosome 13)
- Edwards’ syndrome (trisomy chromosome 18)
- Down’s syndrome (trisomy chromosome 21)
- Turner, Klinefelter, XYY and triple X syndrome (sex chromosome aneuploidies)
- Foetal sex (optional)
- Trisomies in chromosomes 9, 15, 16 and 22
- Cri-du-chat syndrome (Sp)
- 1p36 deletion syndrome
- Microdeletion 2q33.1 syndrome
ADVANCED
- Patau’s syndrome (trisomy chromosome 13)
- Edwards’ syndrome (trisomy chromosome 18)
- Down’s syndrome (trisomy chromosome 21)
- Turner, Klinefelter, XYY and triple X syndrome (sex chromosome aneuploidies)
- Foetal sex (optional)
- Trisomies in chromosomes 9, 15, 16 and 22
- Cri-du-chat syndrome (Sp)
- 1p36 deletion syndrome
- Microdeletion 2q33.1 syndrome
- Van der Woude syndrome 1q32-q41
- DiGeorge 2 syndrome 10p14-p13
- Jacobsen syndrome (deleción 11q)
- Microdeletion syndrome 16p12.2-p11.2
- Autosomal trisomies on all chromosomes
BBSafe®
Process
Collection of maternal blood without risk to the baby.
The test can be performed from week 10 (from week 12 for twin pregnancies). The BBSafe® can also be performed on women who are recipients of oocytes and in vitro fertilisation.
Fetal DNA is found in maternal blood.
Fetal DNA is separated from maternal DNA and sequenced by next-generation techniques (NGS).
We perform a comprehensive analysis of this foetal DNA.
Specific chromosomal alterations are detected in the foetal DNA.
We draw up a personalised report indicating the risk of suffering the different anomalies.
The results report will be delivered within 4 working days, for all options of BBSafe®.
Precision
≥ 99.9 % de sensitivity and specificity
| TRISOMY 13 (Patau syndrome) |
TRISOMY 18 (Edwards syndrome) |
TRISOMY 21 (Down syndrome) |
SEX CHROMOSOMES |
*PARTIAL DELETIONS AND DUPLICATIONS ≥ 7 Mb |
|
|---|---|---|---|---|---|
| SENSITIVITY | 99,9 % | 99,9 % | 99,9 % | 99,9 % | 74,1 % |
| SPECIFICITY | 99,9 % | 99,9 % | 99,9 % | > 85 % | 99,8 % |
* Duplications / deletions (CNVs) with a size greater than or equal to 7 Mb are detected.
BBSafe®
How you will receive the results?
The results are reported as:
LOW RISK o HIGH RISK of presenting the numerical chromosomal alterations studied.In case of a High Risk result, Cerba International offers the option of an invasive prenatal diagnostic test for confirmation at no extra cost.
Fetal sex identification has a high degree of accuracy. This is an optional test.
The NON-valuable result rate of BBSafe® is 0.44%.
